منابع مشابه
Signalling gets sorted by retromer.
Wnt proteins are secreted glycoproteins required for intercellular communication and important for development and tissue homoeostasis. Wnts are secreted through association to the sorting receptor Wntless, which promotes transport of Wnt from the trans-Golgi network (TGN) to the plasma membrane. Harterink et al (2011) and Silhankova et al (2010) have investigated the intracellular recycling of...
متن کاملSpatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-α/β) receptor (IFNAR) is required for JAK/STAT signalling. Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR complex are differentially sorted by t...
متن کاملPublications, Sorted by Subject
[4] D. Haroske. Some logarithmic function spaces, entropy numbers, applications to spectral theory. [9] D. Haroske and H. Triebel. Entropy numbers in weighted function spaces and eigenvalue distribution of some degenerate pseudodifferential operators I. [10] D. Haroske and H. Triebel. Entropy numbers in weighted function spaces and eigenvalue distribution of some degenerate pseudodifferential o...
متن کاملRetromer terminates the generation of cAMP by internalized PTH-receptors
The generation of cAMP by G protein-coupled receptors (GPCRs) and its termination are currently thought to occur exclusively at the plasma membrane of cells. Under existing models of receptor regulation, this signal is primarily restricted by desensitization of the receptors through their binding to β-arrestins. However, this paradigm is not consistent with recent observations that the parathyr...
متن کاملEHDs meet the retromer
Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. Th...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2011.232